Agrisera's H3R2me2(sym)K4me2 antibody - Histone H3 (sym-dimethylated Arg2, dimethyl Lys4) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Precipitation, ChIP, Dot Blot, Immunofluorescence, Immunoprecipitation, and Western Blot. The H3R2me2(sym)K4me2 antibody - Histone H3 (sym-dimethylated Arg2, dimethyl Lys4) was generated using H3 clustered histone 14 as the antigen and it reacts with Homo Sapiens, and Human.
Description
Common histone modifications include methylation of lysine and arginine, acetylation of lysine, phosphorylation of threonine and serine, and sumoylation, biotinylation, and ubiquitylation of lysine. The dimethylation of both arginine 2 (H3R2me2) and lysine 4 (H3K4me2) of H3 are both known marks to have opposing affects. R2me2 maintains transcriptional silence by silencing Set1 mediated K4 methylation, in which K4 methylation is normally associated with active chromatin. The protein arginine methyltransferase PRMT6 can methylate H3R2 in vivo, and overexpression of this enzyme downregulates Hox and Myc dependent genes, both of which are targets of H3K4 methylation